Jayappa Kallesh

Jayappa Kallesh

 Kellesh Jayappa, DVM, PhD, DABT, DABVT

Kallesh Jayappa, DVM, PhD, DABT, DABVT

Assistant Professor, Toxicology

  • DVM: University of Agricultural Sciences, Bangalore, India, 2005
  • MS: Indian Veterinary Research Institute, 2007
  • PhD: University of Manitoba, Canada, 2014

danappajayappa@rowan.edu

Dr. Jayappa is an assistant professor of toxicology. Most recently, he served as an assistant professor of medicine in the Division of Hematology and Oncology at the University of Virginia School of Medicine. His research focuses on both human and animal cancer biology and he has made significant contributions to the field.

Publications

  • Sabzevari A, Ung J, Craig JW, Jayappa KD, Pal I, Feith DJ, Loughran Jr TP, O’Connor OA. Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology. CA Cancer J Clin. 2025 Apr 15. doi: 10.3322/caac.70001
  • Pal I, Illendula A, Joyner A, Manavalan JS, Deddens TM, Sabzevari A, Damera DP, Zuberi S, Marchi E, Fox TE, Dunlap-Brown ME, Jayappa KD, Craig JW, Loughran TP, Feith DJ, O'Connor OA. Preclinical Development of a Romidepsin Nanoparticle Demonstrates Superior Tolerability and Efficacy in Models of Human T-Cell Lymphoma and Large Granular Lymphocyte Leukemia. bioRxiv [Preprint]. 2024 Jul 19:2024.07.18.603379. doi: 10.1101/2024.07.18.603379.
  • Marchi E, Pal I, Manvalan JS, Jayappa KD, O'Connor OA. Epigenetic Drugs as Modulators of Tumor Immunogenicity and Host Immune Response. Precision Cancer Therapies vol 2‐Immunologic Approaches for the Treatment of Lymphoid Malignancies‐From Concept to Practice.
  • Jayappa KD, Tran B, Gordon VL, Christopher M, Saha S, Farrington CC, O’Connor CM, Zawacki KP, Isaac KM, Kester M, Bender TP, Williams ME, Portell CA, Weber MJ, and Narla G. PP2A Modulation Overcomes Multidrug Resistance via Mitochondrial Permeability Transition Pore-Dependent Apoptosis Induction in CLL. J Clin Invest, 2023 May 11; e155938. PMID: 37166997
  • Jayappa KD, Gordon VL, Morris CG, Wison B, Shetty BD, Cios KJ, Arora PC, Isaac KM, Saha S, Bender TP, Williams ME, Portell CA, Weber MJ. Extrinsic interactions in the microenvironment in vivo activate an antiapoptotic multidrug-resistant phenotype in CLL. Blood Adv (2021) 5 (17): 3497–3510. PMID 34432864.
  • Zheng Y, Jayappa KD, Ao Z1, Qiu X, Su RC, Yao X. Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication. Virol J. 2019 Apr 2;16(1):42. PMID 30940169.
  • Jayappa KD, Portell CA, Gordon VL, Capaldo BJ, Bekiranov S, Axelrod MJ, Brett LK, Wulfkuhle JD, Gallagher RI, Petricoin EF, Bender TP, Williams ME, Weber MJ. Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL. Blood Adv.2017 Jun 13;1(14):933-946. PMID 29034364.
  • Jayappa KD, Ao Z, Wang X, Mouland AJ, Shekhar S, Yang X, Yao X. Human immunodeficiency virus type 1 employs the cellular dynein light chain 1 protein for reverse transcription through interaction with its integrase protein. J Virol. 2015 Apr;89(7):3497-511. PMID 25568209.
  • Wang X, Ao Z, Jayappa KD, Shi B, Kobinger G and Yao X. R88-APOBEC3G inhibits the replication of both drug-resistant strains of HIV-1 and viruses produced from latently infected cells. Mol Ther Nucleic Acids. 2014 Mar 4; 3(3): e151. PMID 24594845.
  • Chen L, Ao Z, Jayappa KD, Kobinger G, Liu S, Wu G, Wainberg MA, Yao X. Characterization of antiviral activity of benzamide derivative AH0109 against HIV-1 infection. Antimicrob agents Chemother. 2013 Aug; 57(8): 3547-54. PMID 23669388.
  • Jayappa KD, Ao Z, Yao X. The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration. Int J Biochem Mol Biol. 2012; 3(1):70-85. Epub 2012 Feb 25. PMID 22509482.
  • Ao Z, Jayappa KD, Wang B, Zheng Y, Wang X, Peng J, Yao X. Contribution of host nucleoporin 62 in HIV-1 integrase chromatin association and viral DNA integration. J Biol Chem. 2012 Mar 23;287(13):10544-55. Epub 2012 Feb 3. PMID 22308026.
  • Jayappa KD, Ao Z, Yang M, Wang J, Yao X. Identification of critical motifs within HIV-1 integrase required for importin α3 interaction and viral cDNA nuclear import. J Mol Biol. 2011 Jul 29; 410(5):847-62. PMID 21763491.
  • Zheng Y, Ao Z, Wang B, Jayappa KD, Yao X. Host protein Ku70 binds and protects HIV-1 integrase from proteasomal degradation and is required for HIV replication. J Biol Chem. 2011 May 20; 286(20):17722-35. Epub 2011 Mar 29. PMID 21454661.
  • Ao Z, Wang X, Bello A, Jayappa KD, Yu Z, Fowke K, He X, Chen X, Li J, Kobinger G, Yao X. Characterization of anti-HIV activity mediated by R88-APOBEC3G mutant fusion proteins in CD4+ T cells, peripheral blood mononuclear cells, and macrophages. Hum Gene Ther. 2011 Oct; 22(10):1225-37. Epub 2011 Mar 18. PMID 21182427.
  • Ao Z, Danappa Jayappa K*, Wang B, Zheng Y, Kung S, Rassart E, Depping R, Kohler M, Cohen EA, Yao X. Importin α3 interacts with HIV-1 Integrase and contributes to HIV-1 nuclear import and replication. J Virol. 2010 Sep; 84(17): 8650-63. *Co-first author. PMID 20554775.
  • Zheng Y, Ao Z, Jayappa KD, Yao X. Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase. Virol J. 2010 Mar 23; 7:68. PMID 20331877.
  • Zhujun Ao, Kallesh Danappa Jayappa, Meaghan Labine, Yingfeng Zheng, Chris Matthews, Gary Kobinger and Xiaojian Yao. Characterization of anti-HIV activity mediated by HIV-1 integrase C-terminal domain polypeptides expressed in susceptible cells. Journal of Antivirals & Antiretrovirals, 2010, 2(1): 020-028. DOI:10.4172/jaa.1000017.
  • D J Kallesh, M Hosamani, V Balamurugan,V Bhanuprakash, V Yadav, R K Singh. Quantitative PCR: A quality control assay for estimation of viable virus content in live attenuated goatpox vaccine. Indian J Exp Biol. 2009 Nov; 47(11):911-5. PMID  20099465.
  • Balamurugan V, Jayappa KD, Hosamani M, Bhanuprakash V, Venkatesan G, Singh RK. Comparative efficacy of conventional and taqman polymerase chain reaction assays in the detection of capripoxviruses from clinical samples. J Vet Diagn Invest. 2009 Mar; 21(2):225-31. PMID 19286502.
  • Balamurugan V, Bhanuprakash V, Hosamani M, Jayappa KD, Venkatesan G, Chauhan B, Singh RK. A polymerase chain reaction strategy for the diagnosis of camelpox. J Vet Diagn Invest. 2009 Mar; 21(2):231-7. PMID 19286503.
  • Hosamani M, Bhanuprakash V, Kallesh DJ, Balamurugan V, Pande A, Singh RK. Cell culture adapted sheeppox virus as a challenge virus for potency testing of sheeppox vaccine. Indian J Exp Biol. 2008 Oct; 46(10): 685-9. PMID 19024165.
  • Singh RK, Balamurugan V, Hosamani M, Kallesh DJ, Bhanuprakash V. Sequence analysis of C18L gene of buffalopox virus: PCR strategy for specific detection and differentiation of buffalopox from orthopoxviruses. J Virol Methods. 2008 Dec;154(1-2):146-53. Epub 2008 Sep 30. PMID 18790707.
  • Hosamani M, Yadav S, Kallesh DJ, Mondal B, Bhanuprakash V, Singh RK. Isolation and characterization of an Indian ORF virus from goats. Zoonoses Public Health. 2007; 54 (5):204-8. PMID 17542963.
  • Sharma S, Mahajan V, Hosamani M, Singh RK, Kallesh DJ, Kumar H, Verma S and Sandhu KS (2008). Epidemiology of contagious pustular dermatitis in small ruminants of Punjab. Ind Vet J. 85, 1526-1528 [I096].